“Murder most foul” is one of many allusions to Shakespeare, in this case to
Hamlet. That particular play seeks to deal with the question of the meaning of life, a question which also runs throughout Vonnegut’s novel. John’s natural morality means he can’t help but frame his questions in a way that implies some level of responsibility of science in relation to morality. Dr. Breed believes in “pure research”: scientific work that exists in its own category and needn’t be concerned with anything other than itself.