Bobo’s refusal to eat, as Lorraine’s flashback to the old lady in Manhattan suggests, foreshadows ominous events to come. Readers have known since the book’s beginning that Mr. Pignati will eventually die (it was his death that prompted John and Lorraine to write their confession in the first place), so it’s a fair guess that this scene foreshadows his eventual death, too. As well, it seems like a bad sign that Bobo isn’t eating, so it’s possible that he is in poor health, too. Thus far, the book has emphasized the destructive, negative effects of loneliness and the conversely healing power of friendship, so it makes sense that Mr. Pignati’s worry for Bobo, his self-declared “best friend” (and the grief he’d experience if Bobo were to die) could have a devastating effect on Mr. Pignati’s health.