The alpha helix is a common molecular structure in proteins, which Linus Pauling discovered in 1951. It involves a series of amino acids (or polypeptide chain) arranged in a twisting, helical structure. Pauling’s research…
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Bacteriophages (Phages)
Bacteriophages, or phages for short, are viruses that infect bacteria. Watson began his research career by studying bacteriophages.
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Cambridge Colleges
The University of Cambridge is composed of several dozen smaller colleges that provide accommodation, community, and undergraduate teaching for students.
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Cavendish Laboratory
The Cavendish Laboratory is the prominent laboratory at the University of Cambridge where Watson and Crick conducted their research in the early 1950s and discovered DNA’s double helix structure.
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Crystallography is the study of the structure of crystals (including crystallized biological molecules, like DNA). The most important crystallography technique is X-ray diffraction.
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DNA
Deoxyribonucleic acid, or DNA, is the molecule that carries an organism’s genetic code. Before Crick and Watson discovered its double helix structure in 1953, however, scientists didn’t understand its purpose and strongly disagreed about its…
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Hydrogen Bonds
A hydrogen bond is the weak attractive force between a hydrogen atom in one molecule and the negatively-charged atoms in another molecule (like the oxygen atom in a water molecule). Hydrogen bonds hold together DNA…
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Nitrogenous Bases
Nitrogenous bases are the component of DNA’s nucleotides that encodes genetic information. DNA includes four nitrogenous bases—adenine, thymine, guanine, and cytosine—which are attached to the sugar-phosphate backbone.
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Nucleotide
Nucleotides are the basic components of DNA. In fact, DNA is just a very long chain of nucleotides. Each nucleotide consists of three components: the sugar deoxyribose, a phosphate group, and a nitrogenous…
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Phosphate Groups
The phosphate group is one of the three components of a nucleotide in DNA. Phosphate groups bond with the sugar deoxyribose to form a DNA molecule’s sugar-phosphate backbone.
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The sugar-phosphate backbone is the chain of alternating phosphate groups and deoxyribose sugars that holds together a series of different nucleotides. DNA has two sugar-phosphate backbones, which wrap around each other in a helical…
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Tobacco Mosaic Virus (TMV)
Tobacco mosaic virus (or TMV for short) is a common plant virus. It was the first virus ever discovered, and it’s frequently used in scientific research because it’s easy to produce and poses no danger…
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X-ray Diffraction
X-ray diffraction is an important technique in crystallography. It involves shooting an X-ray beam at a crystal, then measuring how this X-ray beam diffracts (or splits apart in different directions). These diffraction measurements allow…
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